DNA Oestrogen Test

Recommended for:

• Men or women with a strong family history of breast, ovarian, colon or prostate cancer
• Women who suffer from oestrogen-dominant conditions such as endometriosis, premenstrual syndrome and uterine fibroid tumours
• Women considering oral contraceptives, hormone replacement therapy or bio-identical hormone supplementation
• Women who are considering in vitro fertilisation or who have been diagnosed with oestrogen  receptor-positive breast cancer
   

Analytes measured:

CYP1A1:  A phase I cytochrome P450 enzyme that converts environmental pro-carcinogens into reactive intermediates that have carcinogenic effects. It is further involved in the oxidative metabolism of oestrogens.

CYP1B1:  Catalyses the 4-hydroxylation of oestradiol and active polycyclic aromatic hydrocarbons (PAHs)  and arylamines.

CYP17A:  Catalyses reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids as an integral part of the oestrogen metabolism pathway.

MnSOD:  Provides anti-oxidant activity within the cell, necessary for decreasing oxidative damage caused by reactive oestrogen metabolites.

GSTM1:  Responsible for the removal of xenobiotics, carcinogens, and products of oxidative stress, which include reactive oestrogen metabolites.

GSTT1:  A member of a super family of proteins that catalyse the conjugation of reduced glutathione, and is responsible for removal of reactive products of oestrogen metabolism.

COMT:  Influences the levels of certain hormones and is involved in the methylation and inactivation of catechol oestrogens.

MTHFR:  MTHFR is a key enzyme in the folate metabolism pathway – directing folate from the diet either to DNA synthesis or homocysteine re-methylation. Decreased MTHFR enzyme activity has been associated with increased premenopausal breast cancer risk with long duration of oestrogen exposure.

SULT1A1:  Involved in the inactivation of oestrogens and bio-activation of heterocyclic amines and polycyclic aromatic hydrocarbons.

NQO1:  Quinone Reductase is primarily involved in the detoxification of potentially mutagenic and carcinogenic quinones derived from tobacco smoke, diet and oestrogen metabolism.

Factor V:  Factor V Leiden gene mutation is characterized by a poor anticoagulant response to Activated Protein C and an increased risk for venous thromboembolism.

Sample required:  Bloodspot

Average processing time: 18-21 days

Shipping: Test will be shipped to your address and then will be collected from your address and shipped directly to the laboratory

Privacy policy: The DNA and the original sample material are destroyed after 3 months, so that there are no names or other identifiers on the samples. The samples are analysed only for the SNPs that are included in the tests at DNALife, and no other research or analyses are performed without a separate permission from the patient. We do not give or sell the results to any third parties.